L’outil DRomics : Analyse et compréhension de vos données moléculaires obtenues dans un cadre dose-réponse
Omics methods are increasingly used, especially in ecotoxicology, to explore stressor effects at the molecular scale, to investigate pathway responses or to discover new biomarkers.
Applied in a dose response framework, they open new perspectives for mechanistic understanding and risk assessment.
But the specificity and the complexity of their responses require a dedicated workflow to manage properly the data.
DRomics is a tool that was recently developed to help anyone who wants to analyze omics data collected through a dose-response design (https://lbbe.univ-lyon1.fr/-Dromics-.html).
It aims to :
Applied in a dose response framework, they open new perspectives for mechanistic understanding and risk assessment.
But the specificity and the complexity of their responses require a dedicated workflow to manage properly the data.
DRomics is a tool that was recently developed to help anyone who wants to analyze omics data collected through a dose-response design (https://lbbe.univ-lyon1.fr/-Dromics-.html).
It aims to :
- select monotonic and/or biphasic responsive items (e.g. metabolites, transcripts)
- for each selected item, characterize its response by fitting a dose-response curve and calculating an effect concentration (benchmark dose or concentration)
- and globally visualize the dose-response curves of all selected items corresponding to each group defined for example by functional annotation.
- understand the bases of the analysis of omics data and the importance of taking into account the nature of the data (microarray, RNAseq, metabolomics, ...)
- understand the bases of dose-response modeling (nonlinear regression, choice of the bestfit model, calculation of a benchmark dose, estimation of uncertainty , …)
- understand the rationale behind each workflow step to optimize the parameter setting
- learn how to use the DRomics tool (online application and R package for participants with good skills in R)
- explore the outputs of the tool and exchange about their use in downstream analysis
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L’outil DRomics : Analyse et compréhension de vos données moléculaires obtenues dans un cadre dose-réponseLe 06/04/2021 de 09:00 à 12:30Formation à Distance / Valence

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